教師姓名:
李憶菁
職稱:
教授
校內其他職稱: 副研發長
分機:
02-29053411 (office); 02-29053913 (lab)
E-mail:
yjlee@mail.fju.edu.tw
Homepage:
學經歷:
輔仁大學研究倫理中心主任
輔仁大學人體研究倫理委員會執行長
輔仁大學研發處研究管理中心主任
輔仁大學醫學系副教授
輔仁大學醫學系助理教授
英國劍橋大學藥理學博士後研究
英國倫敦大學生理學博士
教學專長:
1. 生理學
2. 神經生理學,神經科學
3. 醫學美容
研究領域:
1. 幹細胞治療視網膜疾病之應用
2. 視網膜退化性疾病之機制與治療
3. 痛覺神經之調控機制
開課資訊
系所
課程
公共衛生學系 生理學
呼吸治療學系 生理學
基礎醫學研究所 神經科學特論
營養學系 人體生理學
臨床心理學系 生理學
職能治療學系 生理學
醫學系 神經運動單元
醫學系 基礎生理學
護理學系 生理學
護理學系 醫學美容概論
著作
  A. 學術期刊論文
  Lee YJ, Chiu CC, Ke CY, Tien N, Lin PK* (2017): Homocysteine
facilitates prominent polygonal angiogenetic networks of a choroidal capillary
sprouting model. Investigative Ophthalmology & Visual Science, 58(10): 4332-
4343. (SCI)

Tien LT, Lee YJ, Pang Y, Lu S, Lee JW, Tseng CH, Bhatt AJ, Savich RD,
Fan LW* (2017): Neuroprotective effects of intranasal IGF-1 against neonatal
lipopolysaccharide-induced meurobehavioral deficits and neuronal inflammation
in the substantia nigra and locus coeruleus of juvenile rats. Developemntal
Neuroscience. in press (SCI)

Chien CC, Huang CJ, Tien LT, Cheng YC, Ke CY, and Lee YJ* (2017):
Suppression of HSP27 restores retinal function and protects photoreceptors
from apoptosis in a light-induced retinal degeneration animal model.
Investigative Ophthalmology & Visual Science, 58(7): 3107–3117. (SCI)

Chien CC, Cai YJ, Tien LT, and Lee YJ* (2017): Subretinal
transplantation of human amniotic membrane mesenchymal stem cell restores
retinal function loss on light-induced retinopathy. Fu-Jen Journal of
Medicine, 15(2): 59-78.

Cheng YP, Ke CY, Kuo CC, and Lee YJ* (2016): Effect of a complex lutein
formula in an animal model for light-induced retinal degeneration. The Chinese
Journal of Physiology, 59(4): 202-209. (SCI)

Cheng YC, Huang CJ, Lee YJ, Tien LT, Ku WC, Chien R, Lee FK, and Chieng
CC* (2016). Knocking down of heat-shock protein 27 directs differentiation of
functional glutamatergic neurons from placenta-derived multipotent cells.
Scientific Reports, 6: 30314. (SCI)

Wang CY, Lin HC, Song YP, Hsu YT, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo
YM, Lee YJ, Hsu CY, and Lee YH* (2015): PKC-dependent GAP43
phosphorylation regulates gephyrin aggregation at developing GABAergic
synapses. Molecular and Cellular Biology, 35: 1712–1726. (SCI)

Lu YC, Wang CC, Lee CM, Hwang KS, Hua YM, Yuh YS, Chiu YL, Hsu WF, Chou YL,
Huang SW, Lee YJ, and Fan HC* (2014): Reevaluating reference ranges of
oxygen saturation for healthy full-term neonates using pulse oximetry.
Pediatrics and Neonatology, 55(6): 459-465. (SCI)

Chen YI, Lee YJ, Wilkie DA, and Lin CT* (2014): Evaluation of potential
topical and systemic neuroprotective agents for ocular hypertension-induced
retinal ischemia-reperfusion injury. Veterinary Ophthalmology, 17(6): 432–442.
(SCI, equal contribution to ChenYI, and LeeYJ)

Chien CC, Lim YT, and Lee YJ* (2014): Retinal transdifferentiation
induced by NeuroD on retinal pigmented epithelial cells. Fu-Jen Journal of
Medicine, 12: 151-160.

Wong CS, Lee YJ, Chiang YC, Fan LW, Ho IK, and Tien LT* (2014): Effect
of prenatal methadone on reinstated behavioral sensitization induced by
methamphetamine in adolescent rats. Behavioural Brain Research, 258: 160-165.
(SCI, equal contribution to WongCS, LeeYJ and ChiangYC)

Lin PK, Ke CY, Khor CN, Cai YJ, and Lee YJ* (2013): Involvement of
SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic
ischemia-induced retinal function loss by mobilizing hematopoietic stem cells.
Investigative Ophthalmology & Visual Science, 54: 1920-1930. (SCI)

Tsai MD, Chen PR, Tien LT, Cai YJ, and Lee YJ* (2013): Nuclear
condensation and cell cycle arrest induced by telomerase siRNA in
neuroblastoma cells. Journal of Neuro-Oncology, 111: 265-272. (SCI)

Wang KC, Lee YJ, Fan LW, Yang PP, Tao PL, Ho IK, and Tien LT* (2013):
Mu-opioid receptor knockout mice are more sensitive to chlordiazepoxide-
induced anxiolytic behavior. Brain Res Bulletin, 90: 137-141. (SCI)

Hu CK, Lee YJ, Colitz CM, Chang CJ, and Lin CT* (2012): The protective
effects of Lycium barbarum and Chrysanthemum morifolum on diabetic
retinopathies in rats. Veterinary Ophthalmology, 15(S2): 65-71. (SCI, equal
contribution to HuCK and LeeYJ)

Hsiao WT, Tsai MD, Jow GM, Tien LT, and Lee YJ* (2012): Involvement of
Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human
retinoblastoma cells. Molecular Vision, 18: 2033-2042. (SCI)

Chien CC, Lee YJ, Fan LW, Ho IK, and Tien LT* (2012): Naloxonazine, a
specific mu-opioid receptor antagonist, attenuates the increment of locomotor
activity induced by acute methamphetamine in mice. Toxicology Letters, 212:
61-65. (SCI, equal contribution to ChienCC and LeeYJ)

Yuan CY, Lee YJ*, and Wang Hsu GS* (2012): Aluminum overload increases
oxidative stress in four functional brain areas of neonatal rats. Journal of
Biomedical Science, 19: 51 (SCI)

Yuan CY, Wang Hsu GS*, and Lee YJ* (2011): Aluminum alters NMDA
receptor 1A and 2A/B expression on neonatal hippocampal neurons in rats.
Journal of Biomedical Science, 18: 81. (SCI)

Ku TH, Lee YJ, Wang SJ, Fan CH, and Tien LT* (2011): Effect of honokiol
on activity of GAD65 and GAD67 in the cortex and hippocampus of mice.
Phytomedicine, 18: 1126-1129. (SCI)

Hu CF, Fan HC, Lai CC, Lee YJ, and Chen SJ* (2011): Chorea: a rare
presentation of moyamoya disease: a case report and literature review. Fu-Jen
Journal of Medicine, 9: 107-112.

Cheng YC, Lee YJ, Huang CJ, Han CT, and Chien CC* (2010): Cytoskeleton
proteomic changes in the process of placenta-derived multipotent cells (PDMCs)
differentiated into neuron. Fu-Jen Journal of Medicine, 8: 1-8. (equal
contribution to ChengYC and LeeYJ)

Cheng CK, Chan KC, and Lee YJ* (2009): Anti-proliferating effect of
beauvericin on retinoblastoma. Fu-Jen Journal of Medicine, 7:161-169.

Fan HC, Lee YJ, and McNaughton PA* (2009): Pain, and why we need it.
Journal of Medical Sciences. 29: 233-241.

Shyu WC, Li KW, Peng HF, Lin SZ, Liu RS, Wang HJ, Su CY, Lee YJ, and Li
H* (2009): Induction of GAP-43 modulates neuroplasticity in PBSC (CD34+)
implanted-Parkinson’s model. Journal of Neuroscience Research, 87: 2020-2033.
(SCI)

Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, and Lee YJ* (2009):
Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal
injection. Retina, 29: 306-312. (SCI)

Peng PH, Huang HS, Lee YJ, Chen YS, and Ma MC* (2009): Novel role for
the δ-opioid receptor in hypoxic preconditioning in rat retinas. Journal of
Neurochemistry, 108: 741-754. (SCI)

Shyu WC, Chen CP, Lin SZ, Lee YJ, and Li H* (2007): Efficient tracking
of non-iron-labeled mesenchymal stem cells with serial MRI in chronic stroke
rats. Stroke, 38: 367-374. (SCI)

Chen CP, Lee YJ, Chiu ST, Shyu WC, Lee MY, Huang SP, and Li H* (2006):
The application of stem cells in the treatment of ischemic diseases. Histology
and Histopathology, 21: 1209-1216. (SCI)

Shyu WC, Lee YJ, Lin SZ, and Li H* (2006): Homing genes, cell therapy
and stroke. Frontiers in Bioscience, 11: 889-907. (SCI)

Lin HI, Lee YJ, Chen BF, Tsai MC, Lu JL, Chou CJ, and Jow GM* (2005):
Involvement of Bcl-2 family, cytochrome C and caspase 3 in induction of
apoptosis by beauvericin in human on-small cell lung cancer cells. Cancer
Letters, 230:248-259. (SCI)

Shyu KG, Jow GM, Lee YJ and Wang SJ* (2005): PP2 inhibits glutamate
release from nerve endings by affecting vesicle mobilization. Neuroreport,
16:1969-1972 (SCI)

Shyu WC, Chen CP, Saeki K, Kubosaki A, Matsumoto Y, Onodera T, Ding DC, Chiang
MF, Lee YJ, Lin SZ and Li H* (2005): Hypoclycemia enhances the
expression of prion protein and heat shock protein 70 in a mouse neuroblastoma
cell line. Journal of Neuroscience Research, 80: 887-894. (SCI)

Shyu WC, Lin SZ, Chiang MF, Pang CY, Chen SY, Hsin YL, Thajeb P, Lee YJ
and Li H* (2005): Early-onset Parkinson’s disease in a Chinese population:
99mTc-TRODAT-1 SPECT, Parkin gene analysis and clinical study. Parkinsonism &
Related Disorders, 11: 173-180. (SCI)

Lee YJ, Wang D., and Jow GM* (2004): Confocal Microscopy in Biomedical
and Clinical applications. Fu-Jen Journal of Medicine, 2:263-271.

Tsai LH*, Lee YJ, and Wu JY (2004): Role of N-methyl-D-aspartate
receptors in gastric mucosal blood flow induced by histamine. Journal of
Neuroscience Research, 77: 730-738. (SCI)

Yang TT, Hung CF, Lee YJ, Su MJ, and Wang SJ* (2004): Morphine inhibits
glutamate exocytosis from rat cerebral cortex nerve terminals (synaptosomes)
by reducing Ca2+ influx. Synapse, 51: 83-90. (SCI)

Huang SP, Lin PK, Liu JH, Khor CN, and Lee YJ* (2004): Intraocular Gene
Transfer of Ciliary Neurotrophic Factor Rescues Photoreceptor Degeneration in
RCS rats. Journal of Biomedical Science, 11: 37-48. (SCI)

Lee YJ, Zachrisson O, Tonge DA, and McNaughton PA* (2002): Upregulation
of bradykinin B2 receptor mRNA and protein expression by neurotrophic factors
and nerve injury in mouse sensory neurons. Molecular Cellular Neuroscience,
19: 186-200. (SCI)

Tsai LH* and Lee YJ (2001): NMDA inhibits oxotremorine-induced acid
secretion via the NO-dependent cyclic GMP system in rat stomach. Chinese
Journal of Physiology, 44: 193-198. (SCI)

Vellani V, Mapplebeck S, Moriondo A, Davis LB, Bonnington JK, Lee YJ,
Zachrisson O, Tonge DA, and McNaughton PA* (2001): Sensitization in
nociceptors. Journal of Physiology, 528: 536P. (SCI)

Lee YJ, Zachrisson O., Tonge D. A., and McNaughton P. A.* (2000):
Effects of media conditioned by lesioned tissue on bradykinin B2 receptor
expression in adult mouse sensory neurons. Journal of Physiology, 523: 91P
(SCI)

Lee YJ, Zachrisson O., Tonge D. A., and McNaughton P. A.* (1999):
Upregulation of bradykinin B2 receptor gene expression in mouse sensory
neurons by NGF and nerve injury. Journal of Physiology, 518: 513P (SCI)

Tsai LH*, Lee YJ, and Wu JY (1999): Effect of excitatory amino acid
neurotransmitters on acid secretion in the rat stomach. Journal of Biomedical
Science, 6: 36-44. (SCI)

  B. 學術會議論文
  Lee YJ*, Ke CY, and Lin PK (2016): Hyperhomocysteinemia caused
chorioretinal vasculopathy in an animal model. European Association for Vision
and Eye Research (EVER) 2016 Congress, T085. Nice, France. Ocotber, 2016.

Lee YJ*, Ke CY, and Lin PK (2016): High level of homocysteine causes
retinal cell loss and choroid thickening in a rat model. The 10th FENS Forum
of Neuroscience 2016, FENS-1736. Copenhagen, Denmark. July, 2016.

Lin PK, Chiu CC, Ke CY, and Lee YJ (2016): Effects of anti-VEGFs on
choroidal vessel outgrowth by an hcy-evoked choroidal capillary sprouting
explant model. The Annual Meeting of the Association for Research in Vision
and Ophthalmology (ARVO) 2016, 4521-B0272. Seattle, Washington, USA. May,
2016.

Tien LT*, Lee YJ, Lee JA, and Fan LW (2015): Neonatal
lipopolysaccharide-induced long-lasting learning impairment and hippocampal
injury was attenuated by IL-1 receptor antagonist in adult rats. Society for
Neuroscience Annual Meeting 2015, 74.14. Chicago, Illinois, USA. October,
2015.

Lee YJ*, Huang CJ, Cheng YC, Tien LT, Ke CY, and Chien CC (2014): HSP27
alters retinal cell existence in a light-induced retinal degenerative model.
Society for Neuroscience Annual Meeting 2014, 433.16. Washington DC, USA.
November, 2014.

Tien LT*, Lee YJ, and Fan LW (2014): Systemic neonatal
lipopolysaccharide-induced brain injury can be ameliorated by melatonin.
Society for Neuroscience Annual Meeting 2014, 528.15. Washington DC, USA.
November, 2014.

Tien LT*, Wong CS, Lee YJ, Chiang YC, Fan LW, and Ho IK (2014): Effect
of prenatal methadone on reinstated behavioral sensitization induced by
methamphetamine in adolescent rats. The 53rd Annual Meeting of the Society of
Toxicology. P369. Phoenix, Arizona, USA. March, 2014.

Huang TC, Li YC, Lee YJ, Tien LT, and Lee JA* (2014): Ameliorative
effects of metformin on aristolochic acid-induced renal toxicity in mice due
to its ability to control methylglyoxal and N-(carboxymethyl)lysine
accumulation. The 53rd Annual Meeting of the Society of Toxicology. P2060.
Phoenix, Arizona, USA. March, 2014.

Chiu CJ, Jow GM, and Lee YJ* (2014): Antioxidant effect of brassica
oleracea sprout extract on ARPE-19 cells. The 29th Joint Annual Conference of
Biomedical Science. P495. March, 2014

Lee YJ*, Tsai MD, Cai YJ, and Tien LT (2013): Possible pathways for
human telomerase RNA interference inhibits cell proliferation of
retinoblastoma cells. Society for Neuroscience Annual Meeting 2013, 446.06.
San Diego, California, USA. November, 2013.

Chen, YC, Tsai MD, Jow GM, Tien LT, and Lee YJ* (2012): Involvement of
p53, smac, and caspase pathways for anti-proliferative effect of 2-
methoxyestradiol on human neuroblastoma cells. Society for Neuroscience Annual
Meeting 2012, 661.07. October, 2012.

Cai YJ, and Lee YJ* (2012): Applications of human amniotic membrane
mesenchymal stem cell on light-induced retinopathy in rats. The 27th Joint
Annual Conference of Biomedical Science. P148. March, 2012.

Tsai MD, Chen PR, and Lee YJ* (2011): Anti-proliferative effect of
telomerase RNA interference on neuroblastoma cell. 13th Asian Australasian
Congress of Neurological Surgeons. Taipei, TAIWAN. December, 2011.

Lee YJ*, Hsiao WT, Tsai MD, Jow GM, and Tien LT (2011): Anti-
proliferating effect of gossypol on human retinoblastoma cells. Society for
Neuroscience Annual Meeting 2011, 678.06. Washington DC, USA. November, 2011.

Tien LT*, Lee YJ, and Ho IK (2011): Naloxonazine, specific mu-opioid
receptor antagonist, inhibits locomotor activity induced by methamphetamine in
mice. Society for Neuroscience Annual Meeting 2011, 81.10. Washington DC, USA.
November, 2011.

Chen YA, Jow GM, and Lee YJ* (2011): Anti-proliferative effect of 2-
methoxyestradiol on retinoblastoma cells. The 7th FAOPS Congress, P-S11.
Taipei, TAIWAN. September, 2011.

Lee YJ*, Lim YT, and Tien LT (2010): Intraocular transplantation of
umbilical cord mesenchymal stem cells rescues retinal functional loss in
lightinduced retinopathy. Experimental Biology 2010 Annual Meeting, LB511.
Anaheim, California, USA. April 2010.

Tien LT*, and Lee YJ (2010): Change in down-stream signaling of
striatal dopaminergic transmission in methamphetamine-sensitized mice.
Experimental Biology 2010 Annual Meeting, LB456. Anaheim, California, USA.
April 2010.

Chang SC, Lee YJ, Yeh YP, Lo PW, Ho IK, and Tien LT* (2010): Change in
down-stream signaling of striatal dopaminergic transmission after
administration of methamphetamine in mice. The 25th Joint Annual Conference of
Biomedical Science, P116. March 2010.

Hsiao WT, Jow GM, and Lee YJ* (2010): The anti-proliferating effect of
gossypol on human retinoblastoma cell ine. The 25th Joint Annual Conference of
Biomedical Science, P649. March 2010.

Cai YJ, Tien LT, Tsai MD, and Lee YJ* (2010): Inhibition of cell
proliferation of retinoblastoma by telomerase RNA interference. The 25th Joint
Annual Conference of Biomedical Science, P860. March 2010.

Lim YT, Tien LT, Lin CT and Lee YJ* (2009): Applications of Wharton’s
jelly cell therapy on light-induced retinopathy in rat model. International
Symposium of Stem Cell and Bioengineering 2009, TSSCR, Tainan, TAIWAN. May
2009.

Lee YJ*, Ke CY, Lin CC, and Chen CP (2007): Transplantation of
mesenchymal stem cell reduces retinal functional loss after retinal ischemia.
Society for Neuroscience 2007: 899.10. San Diego, California, USA. November,
2007.

Tien LT*, Lee YJ, Ma T, Ho IK, and Loh HH (2007): Modulation of u-
opioid receptor on preproenkephalin mRNA expression and opioid and dopamine
receptor binding in methamphetamine-sensitized mice. Japanese Society of
Toxicology, P72, Tokyo, JAPAN. July 2007.

Huang SP, Khor CN, Lee SM, Li H, and Lee YJ* (2004): GCSF rescues
retinal cell apoptosis in transient optic ischemia in the rat. Annual Meeting
of the Association for Research in Vision and Ophthalmology 2004: 3284/B919.

Huang SP*, Lin PK, Lin TN, Lee YJ, Ke CY, Chang Y, Hsu WM, and Liu JH
(2001): Adenovirally expressed ciliary neurotrophic factor rescues
photoreceptor cells in RCS rats. Investigative Ophthalmology & Visual Science,
42: S348.

Lee YJ, Zachrisson O, Tonge DA, and McNaughton PA* (2000): Upregulation
of bradykinin B2 receptor expression in nociceptive neurones by neurotrophic
factors and nerve injury. Society for Neuroscience, 30: 356.11. New Orleans,
Louisana, USA. November, 2000.

近五年來研究計劃
  1. 骨髓間質幹細胞修復視網膜缺血造成視力退化之機轉研究(行政院國家科學委員會)
2. RNA干擾於神經病變性疼痛動物模式之應用 (新光醫院暨輔仁大學學術合作研究計畫)
3. 基因誘導幹細胞治療視網膜退化疾病之研究 (國泰醫院輔仁大學學術合作研究計畫)
4. 以基因誘導幹細胞治療缺血性視網膜退化疾病 (行政院國家科學委員會)
5. 基因轉殖細胞治療視網膜退化疾病的應用 (行政院國家科學委員會)
6. bHLH 轉錄因子治療視網膜退化疾病之應用 (行政院國家科學委員會)

研究室簡介
  1. 幹細胞治療視網膜疾病之研究
2. 視網膜生理及疾病治療之研究
3. 痛覺神經之調控機制及應用
生活照